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MS-2 Cellulaire en moleculaire mechanismen van ... Lin ZB (2005), J Pharmacol Sci., Oct;99(2):144-53 |
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Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
[Cellulaire en moleculaire mechanismen van immuno-modulatie door Ganoderma lucidum]
Inhoud: samenvatting van literatuur die de effecten van polysacchariden van G. lucidum op cellen van het immuunsysteem beschrijft, met name in dierexperimenten en in vitro.
Besproken worden: macrofagen, dendritische cellen, 'natural killer' cellen, T lymfocyten/cellulaire immuunrespons, B lymfocyten/humorale immuunrespons. De polysacchariden van G. lucidum hebben een duidelijk immuno-modulerende werking. Zie tabel (verderop) voor effecten per celtype.
Trefwoorden: Ganoderma lucidum, polysaccharide, immuno-modulation, mechanism.
Soort artikel: overzichtsartikel, overzicht van de literatuur, review.
Taal: engels
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Samenvatting:
Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
Lin ZB
J Pharmacol Sci. 2005 Oct;99(2):144-53.
Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi or Reishi) has been
used for a long time in China to prevent and treat various human
diseases. G. lucidum polysaccharides extracted from G. lucidum are one
of efficacious ingredient groups of G. lucidum. A number of reports
have demonstrated that G. lucidum polysaccharides modulate immune
function both in vivo and in vitro. The immuno-modulating effects of G.
lucidum polysaccharides were extensive, including promoting the
function of antigen-presenting cells, mononuclear phygocyte system,
humoral immunity, and cellular immunity. Cellular and molecular
mechanisms, possible receptors involved, and triggered signaling
cascades have also been studied in vitro. However, whole animal
experiments are still needed to further establish the mechanism of the
immuno-modulating effects by G. lucidum. Evidence-based clinical trials
are also needed.
Tabel:
In onderstaande tabel wordt de effecten van G. lucidum polysacchariden op verschillende cellen van het immuunsysteem samengevat, met
verwijzing naar de bijbehorende referentie. Kijk voor de volledige
referentie - via bovengenoemde URL - in het bijbehorende PDF-document.
Table 1. The effects of Ganoderma lucidum polysaccharides on immune
cells
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Macrophages
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GL-Polysaccharides......
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Enhance
phagocytosis (refs. 1, 2, 7) in macrophages
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Promote IL-1, TNFα production
and TNFα mRNA expression (3 - 6)
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Prevent oxidant tBOOH-induced oxidative
injury (8 - 10)
- Protect mitochondrial membrane and
alleviate membrane injury by free radicals (10)
- Increase [Ca2+] (12)
- Induce IP3 and
DAG formation (13)
- Increase PKC activity (14)
- Activate macrophages via TLR4 and TLR4-modulated
protein kinase signaling pathways (18, 19)
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Neutrophils
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Increase in PKC, MAPK, HCK and tyrosine
kinase Lyn activities (16)
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Inhibit spontaneous and Fas-induced
apoptosis by activation of Akt-regulated signaling pathways (17)
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Dendritic cells
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Promote maturation and immune response
initiation induced by DC (20)
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Promote cytotoxicity of specific CTL
induced by DC (21)
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Increase IFNγ and
granzyme B production and mRNA expression (21)
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Induce activation and maturation of human
DC by the NF-κB and p38 MAPK pathways (22)
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Natural killer cells
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Enhance activity of NK cells (1)
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Increase NK-cell-mediated cytotoxicity (23)
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T lymphocytes
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Increase lymphocyte proliferation induced
by ConA and MLC (24, 25)
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Promote IL-2, IFN-γ production
(5, 25)
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Increase DNA synthesis and enhance activity
of DNA polymerase α (25)
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Increase the percentage of CD5+, CD4+ and
CD8+ T-lymphocytes (31)
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Increased production of IP3 and DAG (32)
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Increase activities of PKA and PKC (33)
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B lymphocytes
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Increase lymphocyte proliferation induced
by LPS (34, 35)
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Increase in secretion of immunoglobulin (36)
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Stimulate expression of PKC (36)
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Reduced mucosal specific IgA response of
young adult mice orally immunized with cholera toxin (38)
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